WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Tight junction       ID:04530
C=132; O=4; E=0.24; R=16.54; rawP=0.0001; adjP=0.0013
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119139 NA TJP2 tight junction protein 2 9414 ENSG00000119139
2  ENSG00000180104 NA EXOC3 exocyst complex component 3 11336 ENSG00000180104
3  ENSG00000105357 NA MYH14 myosin, heavy chain 14, non-muscle 79784 ENSG00000105357
4  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:KEGG pathway       Name:Regulation of autophagy       ID:04140
C=34; O=2; E=0.06; R=32.11; rawP=0.0018; adjP=0.0087
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
2  ENSG00000139112 NA GABARAPL1 GABA(A) receptor-associated protein like 1 23710 ENSG00000139112


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=3; E=0.25; R=12.13; rawP=0.0020; adjP=0.0087
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130939 NA UBE4B ubiquitination factor E4B 10277 ENSG00000130939
2  ENSG00000167986 NA DDB1 damage-specific DNA binding protein 1, 127kDa 1642 ENSG00000167986
3  ENSG00000215218 NA UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 134111 ENSG00000215218


Database:KEGG pathway       Name:mTOR signaling pathway       ID:04150
C=52; O=2; E=0.10; R=21.00; rawP=0.0041; adjP=0.0133
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177169 NA ULK1 unc-51-like kinase 1 (C. elegans) 8408 ENSG00000177169
2  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:KEGG pathway       Name:RNA degradation       ID:03018
C=71; O=2; E=0.13; R=15.38; rawP=0.0076; adjP=0.0198
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000080802 NA CNOT4 CCR4-NOT transcription complex, subunit 4 4850 ENSG00000080802
2  ENSG00000183864 NA TOB2 transducer of ERBB2, 2 10766 ENSG00000183864


Database:KEGG pathway       Name:Small cell lung cancer       ID:05222
C=85; O=2; E=0.16; R=12.84; rawP=0.0107; adjP=0.0232
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
2  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=3; E=0.60; R=5.02; rawP=0.0222; adjP=0.0335
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000173207 NA CKS1B CDC28 protein kinase regulatory subunit 1B 1163 ENSG00000173207
2  ENSG00000085741 NA WNT11 wingless-type MMTV integration site family, member 11 7481 ENSG00000085741
3  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=2; E=0.23; R=8.60; rawP=0.0229; adjP=0.0335
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174231 NA PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) 10594 ENSG00000174231
2  ENSG00000099995 NA SF3A1 splicing factor 3a, subunit 1, 120kDa 10291 ENSG00000099995


Database:KEGG pathway       Name:Osteoclast differentiation       ID:04380
C=128; O=2; E=0.23; R=8.53; rawP=0.0232; adjP=0.0335
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000161011 NA SQSTM1 sequestosome 1 8878 ENSG00000161011
2  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=2; E=0.25; R=7.91; rawP=0.0267; adjP=0.0347
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000164776 NA PHKG1 phosphorylase kinase, gamma 1 (muscle) 5260 ENSG00000164776
2  ENSG00000105221 NA AKT2 v-akt murine thymoma viral oncogene homolog 2 208 ENSG00000105221




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).